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Arch <br />Chemicals„ <br />Inc. <br />[s1to] III1Xr . I UOTI-6111 <br />Not known or reported to cause reproductive or <br />developmental toxicity. <br />Mutagenicity: Calcium hypochlorite has been tested in the Dominant lethal assay in male <br />mice, and it did not induce a dominant lethal response. Calcium hypochlorite <br />has been reported to produce mutagenic activity in two in vitro assays. It <br />has, however, been shown to lack the capability to produce mutations in <br />animals based on results from the micronucleus assay. In vitro assays <br />frequently are inappropriate to judge the mutagenic potential of bactericidal <br />chemicals due to a high degree of cellular toxicity. The concentration which <br />produces mutations in these in vitro assays is significantly greater than the <br />concentrations used for disinfection. Based on high cellular toxicity in in vitro <br />assays and the lack of mutagenicity in animals, the risk of genetic damage <br />to humans is judged not significant. <br />CALCIUM CHLORIDE This product was determined to be non-mutagenic in <br />the Ames assay. It was also shown to be non- <br />clastogenic in the chromosomal aberration test. <br />Carcinogenicity: This product is not known or reported to be carcinogenic by any reference <br />source including IARC, OSHA, NTP or EPA. One hundred mice were <br />exposed dermally 3 times a week for 18 months to a solution of calcium <br />hypochlorite. Histopathological examination failed to show an increased <br />incidence of tumors. IARC (International Agency for Research on Cancer) <br />reviewed studies conducted with several hypochlorite salts. IARC has <br />classified hypochlorite salts as having inadequate evidence for <br />carcinogenicity to humans and animals. IARC therefore considers <br />hypochlorite salts to be not classifiable as to their carcinogenicity to humans <br />(Group 3 Substance). <br />CALCIUM CHLORIDE This chemical is not known or reported to be <br />carcinogenic by any reference source including IARC, <br />OSHA, NTP, or EPA. <br />SECTION 12. ECOLOGICAL INFORMATION <br />Overview: Highly toxic to fish and other aquatic organisms. <br />Ecological Toxicity Values for: CALCIUM HYPOCHLORITE <br />Bluegill <br />Rainbow trout (Salmo gairdneri), <br />Daphnia magna, <br />Bobwhite quail <br />Mallard ducklings <br />Bobwhite quail <br />- (nominal, static). 96 h LC50 0.088 mgll <br />- (nominal, static). 96 h LC50 0.16 mgll <br />- (nominal, static). 48 h LC50 0.11 mgll <br />- Dietary LC50 > 5,000 ppm <br />- Dietary LC50 > 5,000 ppm <br />- Oral LD50 3,474 mg/kg <br />Ecological Toxicity Values for: CALCIUM CHLORIDE <br />Bluegill - (nominal, static). 96 h LC50 = 10,650 mg/1 <br />Mosquito fish - (nominal, static). 96 h LC50 = 13,400 mgll <br />Pulsar Plus Calcium Hypochlorite Briquettes <br />REVISION DATE: 06/02/2015 Page 9 of 13 <br />