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CLAKIFLOCT"' CE-1463 <br />Serious eye damage/eye irritation: Not irritating. (OECD 405) (SNF) <br />Respiratory/skin sensitisation: Not sensitizing. <br />Mutagenicity: Negative in the Ames Test (OECD 471). Negative in the In vitro Mammalian Cell <br />Gene Mutation Test (OECD 476). <br />Carcinogenicity: Based on available data, product is not expected to be carcinogenic. <br />Carcinogenicity study in rat: NOAEL > 750 mg/kg/day <br />Reproductive toxicity: Based on available data, product is not expected to be toxic for reproduction. <br />NOAEL/Maternal toxicity/rat >= 288 mg/kg/day <br />NOAEL/Developmental toxicity/rat >= 288 mg/kg/day <br />STOT -Single exposure: No known effects. <br />STOT -Repeated exposure: No known effect. <br />Aspiration hazard: No known effects. <br />Sulfamic acid <br />Acute oral toxicity: LD50/orailrat = 2065 - 2140 m�kg <br />Acute dermal toxicity: NOAEL/dermal/rat = 2000 mg/kg (OECD 402) <br />Acute inhalation toxicity: The product is not expected to be toxic by inhalation. <br />Skin corrosion/irritation: Not irritating. (OECD 404) (SNF) <br />Serious eye damage/eye irritation: Moderately irritating to the eyes. (EPA OPPTS 870.2400) <br />Respiratory/skin sensitisation: The product is not expected to be sensitizing. <br />Mutagenicity: Negative in the Ames Test (OECD 471). Negative in the In vitro Mammalian Cell <br />Gene Mutation Test (OECD 476). Not mutagenic. (OECD 472, 487) <br />Carcinogenicity: Based on the absence of mutagenicity, it is unlikely that the substance is carcinogenic. <br />Reproductive toxicity: Based on available data, product is not expected to be toxic for reproduction. <br />Prenatal Development Toxicity Study (OECD 414) <br />- NOAELlMaternal toxicity/rat = 200 mg/kg/day <br />- NOAEL/Developmental toxicity/rat = 200 mg/kg/day <br />Print Date: 0511012024 Revision date: 0210312023 Page: 8 / 15 <br />