Opening of Bids - Eight Cardiac Monitors Defibrillators - Physio-Control, Inc. - Part 2

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I.- sEryker ,Evolution in ECG Interpretation 100001 University of Gl�asgo,w ECG analysis prograrr no 0 111111111,060 LIFEPAKO 15 rnonitor/defibrillator Key definitions STEMI (ST elevation myocardial ischemia/infarction) STJ level (ST level at J point, QRS end) STEMI imposter (non-ischemic cause of ST elevation) Sensitivity for STEMI (% of STEMI patients who got a STEMI interpretation) Specificity for STEMI (% of patients without STEMI who do not get a STEMI interpretation) False positive rate (% of patients without STEMI who got a STEMI interpretation, = 100% - specificity) Positive predictive value (% of STEMI interpretations that are actually STEMI; this is strongly affected by STEM11 prevalence in the population who get 12-leads 12-lead ECG interpretive programs are not created equal The Glasgow ECG analysis program has been used around the world and refined over 30 years.' It is considered to be among best -in -class by cardiologists.' The LIFEPAK 15 monitor/defibrillator currently uses Glasgow version 27.1," As a trusted EGG interpretive algorithm, the Glasgow program offers many leading clinical advantages and has proven performance for STEMI analysis." Published performance Published performance in hospital and prehospitat environments should be a standard expectation of any 12-lead EGG interpretation program. The Glasgow ECG analysis program has been well -studied in both clinical settings. • Four published articles on STEMI detection in prehospital use • Over 100 published articles on detection of arrhythmias and morphology abnormalities Tuscon data (Macfarlane 2004)�, 1,220 patients with chest pain N/A 98.5% 1.5% Tuscon data (Macfarlane 20071" 300 patients with chest pain 89% N/A N/A . . . ........ . — Denmark data (Clark 2010) 912 patients with AGS symptoms 78% 94% 6% Los Angeles data (Bosson 2017)8 44,611 patients wrth 12-lead ECGs 92,8% 98,7% 1.3% Note: Sensitivity and specificity for STEMI should not be cornpared between different EGG interpretive programs unless testing was done with the, same 12-fead ECG data set. Clinical advantages The Glasgow ECG analysis program incorporates key clinical features to assist clinicians with diagnostic assessment of patients with challenging fit -leads. • STEMI thresholds based on age and gender as recommended by the AHNACCRES01" • Measures ST level at the point for STEMI as recommended by the AHA/ACCF/ESCIO-11 • Uses Sgarbossa criteria for STEMI detection in LBBB as recommended by the AHNACCRESC"m "' • Provides interpretive analysis statements for adult and pediatric patients"' • Includes criteria for Brugada pattern, a non-ischemic cause of ST elevation